This ancient city of Asia Minor, located in Syria on the Orontes River, was held to be one of the three great Episcopal cities in apostolic times.
It was at Antioch that the name Christian arose (Acts 11:26), and there St. Peter was bishop for a time before going to Rome.
In early times it was a center of theology and scriptural studies.
It was called Antioch in Syria to distinguish it from the other ancient city of the same name in Phrygia, located in modern day western Turkey. (7:32)